Official FOX Synopsis:
HOUSE, an innovative take on the medical drama, solves mysteries where the villain is a medical malady and the hero is an irreverent, controversial doctor who trusts no one, least of all his patients.

DR. GREGORY HOUSE (Hugh Laurie) is devoid of bedside manner and wouldn’t even talk to his patients if he could get away with it. Dealing with his own constant physical pain, he uses a cane that seems to punctuate his acerbic, brutally honest demeanor. While his behavior can border on antisocial, House is a brilliant diagnostician whose unconventional thinking and flawless instincts afford him a great deal of respect. An infectious disease specialist, he thrives on the challenge of solving medical puzzles in order to save lives.

Season 4
Alone - 9/25/07
The Right Stuff - 10/2/07
97 Seconds - 10/9/07
Guardian Angels - 10/23/07
Mirror Mirror - 10/30/07
Whatever It Takes - 11/6/07
Ugly - 11/13/07
You Don't Want to Know - 11/20/07
Games - 11/27/07
It's a Wonderful Lie - 1/29/08
Frozen - 2/3/08
Don't Ever Change - 2/5/08

Hugh Laurie (Dr. Gregory House)
Lisa Edelstein (Dr. Lisa Cuddy)
Omar Epps (Dr. Eric Foreman)
Robert Sean Leonard (Dr. James Wilson)
Jennifer Morrison (Dr. Allison Cameron)
Jesse Spencer (Dr. Robert Chase)

House Uses a Cane
Some years before the show started, House had a blood clot in his right leg that went undiagnosed by his doctors, thereby causing his thigh muscles to die off. He eventually diagnosed it himself, and then Stacy, his girlfriend at the time, waited for him to go into a coma so that she could consent to surgery to remove the dead tissue, leaving him with the reduced leg function and pain that necessitates a cane and an addiction to painkillers.